e-selectin s128r polymorphism leads to severe asthma
نویسندگان
چکیده
the e-selectin mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of asthma. it has been suggested that an s/r (serine128arginine) polymorphism of e-selectin alters ligand binding function. our purpose in this study was to determine whether this serine128arginine polymorphism influences the risk of asthma and also to analyze the possible correlation of disease severity in iranian patients with polymorphism of e-selection. we studied human e-selectin gene polymorphism in 172 asthmatic patients and 173 healthy volunteers by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp). to determine the severity of the asthma’s situation, a questionnaire was prepared requesting the following information: age, sex, clinical signs and symptoms and past medical history. after the participants filled in the questionnaire, all active or ex-smoker patients were excluded. a trained observer assessed airway reversibility, peak flowmetry and spirometry in asthmatic patients. we found increased serum levels of soluble e-selectin (se-selectin) in asthmatic patients compared with healthy subjects (p these results suggest that the ser128arg polymorphism of the e-selectin gene is a genetic factor that may be associated with the severity of asthma.
منابع مشابه
E-selectin S128R polymorphism leads to severe asthma.
The E-selectin mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of asthma. It has been suggested that an S/R (Serine128Arginine) polymorphism of E-selectin alters ligand binding function. Our purpose in this study was to determine whether this Serine128Arginine polymorphism influences the risk of asthma and also to analyze ...
متن کاملEnhanced recruitment of Th2 and CLA-negative lymphocytes by the S128R polymorphism of E-selectin.
E-selectin is a cytokine-inducible endothelial cell adhesion molecule that binds a restricted population of T lymphocytes consisting of Th1 memory cells bearing the cutaneous lymphocyte Ag (CLA). A serine to arginine (S128R) polymorphism in E-selectin has been reported at increased frequency in patients with systemic lupus erythematosus and atherosclerosis. Here we tested the hypothesis that th...
متن کاملImplications of the E-selectin S128R mutation for drug discovery.
The C-type lectin E-selectin mediates the rolling of circulating leukocytes on vascular endothelial cells during the inflammatory process. In numerous studies, the S128R mutation of the E-selectin was associated with cardiovascular and autoimmune diseases. There is evidence that the S128R E-selectin mutation leads to a loss in ligand specificity, thus increasing leukocyte recruitment. Apart fro...
متن کاملE-selectin polymorphism in erythema nodosum secondary to sarcoidosis.
OBJECTIVE E-selectin is expressed on cytokine-stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. An A/C polymorphism at position +561 in the E-selectin gene, which yields an amino acid exchange from serine to arginine at position 128 in the epidermal growth factor-like domain, has been described. We have assessed whe...
متن کاملElevation of serum soluble E-selectin and VCAM-1 in severe asthma.
OBJECTIVE To investigate the significance of circulating adhesion molecules associated with leucocyte-endothelial cell interactions in asthma, serum levels of soluble E (sE)-selectin, soluble P (sP)-selectin, soluble L (sL)-selectin, and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured in mild, moderate and severe asthma. METHOD Serum levels of sE-selectin, sP-selectin, sL-se...
متن کاملSoluble E-selectin and P-Selectin Serum Levels in Patients with Psoriasis Compared to Healthy Controls
Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEsele...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۶، شماره ۲، صفحات ۴۹-۵۷
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023